Thomas POISSON

Welcome to our website!

Our research group is located at INSA ROUEN NORMANDIE UMR6014 COBRA and our research is devoted to the development of new methods for organic chemistry

NEWS

02.2020 Our new website just started

The Group

Graduate Students

3rd Year                                              

Pauline Poutrel

Augustin Nouaille

2nd Year                 

Thibaud Brégent                  

Mingbing Zhong                 

Louise Ruyet 

1st Year                                        

Nicolas Troude 

Maude Aelterman 

Romain Lapierre 

Postdoctoral Research Associate

Dr. Ludovic Leleu

Dr. Mathieu Arribat

Dr. Morgan Languet

Dr. Thi Minh Thi Le   

Our Research

+ Development of New Methodologies for Organic Synthesis

+ Metal-Catalyzed Reactions – Copper Chemistry

+ Electron Transfer Based Reactions

+ Fluorinated Molecules

+ Asymmetric Catalysis

+ Continuous Flow process

Thomas

 

Biosketch:

After a Master degree with honor from the University of Rouen (France), I received my PhD at Rouen University in 2009 under the mentorship of Dr. Vincent Levacher, working on the development of new catalytic enantioselective protonation reactions. Afterwards, I joined the group of Prof. Shū Kobayashi (Tokyo University) as a JSPS fellow, working on asymmetric catalysis using alkaline earth metal complexes. Then, I joined the group of Prof. Magnus Rueping (RWTH-Aachen) as a postdoctoral fellow working on the design of new photocatalyzed reactions. In 09/2011, I was appointed as a “Maître de Conférences” (Associate Professor with tenure) at INSA ROUEN NORMANDY and I defended my habilitation in December 2015. In 2017, I was nominated as a Junior Member of the “Institut Universitaire de France” and since 2018, I am Full Professor of Chemistry at INSA ROUEN NORMANDY UMR 6014 COBRA, FRANCE. My research interests focus on the development of new methodologies, metal-catalyzed reactions, with a strong emphasis on copper chemistry, electron transfer based reactions, asymmetric catalysis and fluorinated molecules.


Awards:

Junior Member of the “Institut Universitaire de France” (IUF) 2017 – 2022.

Junior scientists participation Fellowship (52nd Bürgenstock Conference) 2017. 

Thieme Chemistry Journal Award 2017.

Young Lecturer Award from the Organic Division of the French Chemical Society (SCF) 2016.

Junior distinguished member of the French Chemical Society (SCF) 2015 – 2020.

Fellowship of the Japan Society for Promotion of Science (JSPS) 2009 – 2010.

Graduate Fellowship from the French government 2005 – 2009.

Master Fellowship 2004 – 2005.

Publications

2020 (4)

78. Synthesis of Fluorocyclopropanes via the Enantioselective Cyclopropanation of Fluoro-substituted Allylic Alcohols using Zinc Carbenoids. (Invited Contribution to a Special Issue dedicated to the 100th anniversary of the Department of Chemistry and the Université de Montréal).

Can. J. Chem. 2020, accepted

Delion, L.; Pannecoucke, X.; Poisson, T.; Jubault, P.; Charette, A. B.

77. Recent Advances in Photocatalyzed Reactions Using Well-defined Copper(I) Complexes. (review: Invited Contribution to a Special Issue on Copper Chemistry, Editors: Profs. Gwilherm Evano & Olivier Riant).

Beilstein J. Org. Chem. 202016, 451

Zhong, M.; Pannecoucke, X.; Jubault, P.; Poisson, T.

76. Practical Synthesis of Ethyl 3-Fluoro-1-Pyrrole-2 Carboxylate: a Key Fragment of a potent drug candidate against Hepatitis B virus.

Org. Process. Res. Dev. 2020, DOI:10.1021/acs.oprd.9b00382.

René, A.; Quilan, M.; Deng, Y.; Cheng, Y.; Teleha, C. A.; Raboisson, P.; Bonfanti, J.-F.; Fortin, J.; Charette, A. B.; Pannecoucke, X.; Poisson, T.; Jubault, P.

75. N-Heterocyclic Carbene-Catalyzed Formal [6+2] Annulation Reaction via Cross-Conjugated Aza-Trienolate Intermediates.

Chem. Eur. J. 2020, 26, 818.

Balanna, K.; Krishnaprasad M.;  Mukherjee, S.; Ghosh, A.; Poisson, T.; Besset, T.; Jindal, G.; Biju, A.T.

 

2019 (7)

74. Copper-Catalyzed Enantioselective Formation of C-CF3 Centers from b-CF3-Substituted Acrylates and Acrylonitriles.

Chem. Eur. J. 201925, 15262.

Poutrel, P.; Ivanova, M. V.; Pannecoucke, X.; Jubault, P.; Poisson, T.

73. Catalytic Asymmetric Synthesis of a,a-Difluoromethylated and a-Fluoromethylated Tertiary Alcohols.

Org. Lett. 2019, 21, 7509.

Huang, W.-S.; Delcourt, M.-L.; Pannecoucke, X.; Charette, A. B.; Poisson, T.; Jubault, P.

72. BiCl3-Mediated Direct Functionalization of Unsaturated C–C Bonds with an Electrophilic SCF2PO(OEt)2Reagent.

Chem. Commun. 201955, 8784.

Wang, J.; Xiong, H.-Y.; Petit, E.; Bailly, L.; Pannecoucke, X.; Poisson, T.; Besset, T.

71. Recent Advances for the Direct Introduction of the CF2Me Moiety (Review).

Front. Chem. 20197, article 111.

Carbonnel, E.; Poisson, T.; Jubault, P. ; Pannecoucke, X.; Besset, T.

70. Catalytic Enantioselective Cyclopropanation of a-Fluoroacrylates: An Experimental and Theoretical Study.

ACS Catal. 2019, 9, 2594.

Pons, A.; Tognetti, V.; Joubert, L.; Poisson, T.; Pannecoucke, X.; Charette, A. B.; Jubault, P.

69. Copper Photocatalyzed Borylation of Organic Halides under Batch and Continuous Flow Conditions.

Chem. Eur. J. 2019, 25, 3262.

Nitelet, A.; Thevenet, D.; Schiavi, B.; Hardouin, C.; Fournier, J.; Tamion, R.; Pannecoucke, X.; Jubault, P.; Poisson, T.

68. Rhodium Catalysed Enantioselective Synthesis of Mono-(halo)-methyl-cyclopropanes. (Invited contribution for a web themed issue on Carbenes in Organic Synthesis, Guest Editors: Prof. Jianbo Wang, Prof. Anita R. Maguire and Prof. Michael P. Doyle).

Org. Biomol. Chem. 201917, 472.

Schlinquer, C.; Huang, W.-S.; Chen, L.; Poisson, T.; Pannecoucke, X.; Charette, A. B.; Jubault, P.

 

2018 (10)

67. Enantioselective NHC-Catalyzed Cascade Reaction for the Synthesis of Pyrroloquinolines via N-H Functionalization of Indoles.

Org. Lett. 201820, 6998.

Mukherjee, S.; Shee, S.; Poisson, T.; Besset, T.; Biju, A. T.

66. Pd-Catalyzed Trifluoromethylthiolation of Unsaturated Compounds: A General Approach. (Invited contribution for a special issue on C-H Activation in Organic Synthesis).

Eur. J. Org. Chem2018, 6167.

Zhao, Q.; Chen, M.-Y.; Poisson, T.; Pannecoucke, X.; Bouillon, J.-P.; Besset, T.

65. Palladium-Catalyzed Synthesis of 3-trifluoromethylated 1,3-dienes from Acrylate Derivatives and BTP. (Invited contribution for the Tetrahedron Symposium in Print on Organofluorine Chemistry, Guest Editor: Prof. Feng-Ling Qing).

Tetrahedron 201874, 6033.

Zhao, Q.; Wang, J.; Besset, T.; Pannecoucke, X.; Bouillon, J.-P.; Poisson, T.

64. N-Heterocyclic Carbene-Catalyzed Synthesis of a-Trifluoromethyl esters.

Org. Lett. 201820, 3897.

Gelat, F.; Patra, A.; Pannecoucke, X.; Biju, A. T.; Poisson, T.; Besset, T.

63. General Catalytic Enantioselective Access to Monohalomethyl and Trifluoromethyl Cyclopropanes.

Chem. Eur. J. 201824, 10339.

Huang, W.-S; Schlinquer, C.; Poisson, T.; Pannecoucke, X.; Charette, A. B.; Jubault, P.

62. Trifluoromethylthiolation of a-Chloroaldehydes: Access to Quaternary SCF3-containing Centers. (Invited contribution for a special issue on Organofluorine chemistry in Europe).

Eur. J. Org. Chem. 2018, 3897.

Gelat, F.; Poisson, T.; Biju, A. T.; Pannecoucke, X.; Besset, T.

61. 1-C-Phosphonomethyl- and 1-C-Difluorophosphonomethyl-1,4-imino-l-arabinitols as Galf Transferase Inhibitors: A Comparison.

Carbohydr. Res. 2018461, 45.

Cocaud, C.; Zheng, R. B.; Lowary, T. L.; Poisson, T.; Pannecoucke, X.; Nicolas. C.; Martin, O. R.

60. An Electrophilic Reagent for the Synthesis of OCHFMe-containing Molecules. 

Chem. Commun. 201854, 2491.

Carbonnel, E.; Pannecoucke, X.; Besset, T.; Jubault, P., Poisson, T.

59. Synthesis of 4-Difluoromethyl Quinolines by N-Heterocyclic Carbene (NHC)-Catalyzed Umpolung of Imines.

Org. Lett. 201820, 1086. 

Patra, A.; Gelat, F.; Pannecoucke, X.; Poisson, T.; Besset, T.; Biju, A. T.

58. Palladium-Catalyzed Synthesis of Aryl and Heteroaryl difluoromethylated Phosphonates. (invitation - Bürgenstock Special Section 2017 Future Stars in Organic Chemistry)

Synthesis 201850, 778.

Ivanova, M.; Besset, T.; Pannecoucke, X.; Poisson, T.

 

2017 (10)

57. Copper-Mediated Introduction of the CF2PO(OEt)2 Motif: Scope and Limitations.

Chem. Eur. J. 201723, 17318.

Ivanova, M. V.; Bayle, A.; Besset, T.; Pannecoucke, X.; Poisson, T.

56. Pd-Catalyzed Diastereoselective Trifluoromethylthiolation of Functionalized Acrylamides.

Org. Lett. 201719, 5106.

Zhao, Q.; Poisson, T.; Pannecoucke, X.; Bouillon, J.-P.; Besset, T.

55. Catalytic Enantioselective Synthesis of Highly Functionalized Difluoromethylated Cyclopropanes.

Angew. Chem. Int. Ed. 201756, 13319.

Bos, M.; Huang, W.; Poisson, T.; Pannecoucke, X.; Charette, A. B.; Jubault, P.

54. The Transient Directing Group Strategy: a New Trend in Transition Metal Catalyzed C-H Bond Functionalization. (Review)

Synthesis 201749, 4808.

Zhao, Q.; Poisson, T.; Pannecoucke, X.; Besset, T.

53. [18F]Fluoroform: a [18F]trifluoromethylating agent for the synthesis of SCF218F - aromatic derivatives.

Chem. Commun. 2017, 53, 5706.

Carbonnel, E.; Besset, T.; Poisson, T.; Labar. D.; Pannecoucke, X; Jubault, P.

52. Palladium Catalyzed Synthesis of 3-Trifluoromethyl Substituted 1,3-Butadienes by Means of Directed C-H Bond Functionalization.

Org. Lett. 201719, 2106.

Zhao, Q.; Tognetti, V.; Joubert, L.; Besset, T.; Pannecoucke, X.; Bouillon, J.–P.; Poisson, T.

51. Stereoselective Access to Trisubstituted Fluorinated Alkenyl Thioethers.

Catal. Sci. Technol. 20177, 1921.

Fabre, I.; Poisson, T.; Pannecoucke, X.; Gillaizeau, I.; Ciofini, I.; Grimaud, L.

50. Copper Mediated (Diethyl phosphono)difluoromethylthiolation of a-Bromo-Ketones.

Eur. J. Org. Chem. 2017, 2475.

Ivanova, M. V.; Bayle, A.; Besset, T.; Pannecoucke, X.; Poisson, T.

49. Tunable Approach for the Stereoselective Synthesis of 1-C-Diethylphosphono(difluoromethyl) Iminosugars as Glycosyl Phosphate Mimics.

J. Org. Chem. 2017, 82, 2753.

Cocaud, C.; Nicolas, C.; Poisson, T.; Pannecoucke, X.; Legault, C. Y.; Martin, O. R.

48. Recent Progress Toward the Synthesis of Trifluoromethyl and Difluoromethyl Substituted Cyclopropanes. (Review)

Chem. Eur. J. 201723, 4950.

Bos, M.; Poisson, T.; Pannecoucke, X.; Charette, A. B.; Jubault, P.

 

2016 (7)

47. Copper Salt-Controlled Divergent Reactivity of [Cu]CF2PO(OEt)2 with a-Diazocarbonyl Derivatives.

Angew. Chem. Int. Ed. 2016, 55, 14141.

Ivanova, M. V.; Bayle, A.; Besset, T.; Pannecoucke, X.; Poisson, T.

46. Synthesis and Applications of Fluorocyclopropanes. (Review – invitation)

Synthesis 201648, 4060.

Pons, A.; Poisson, T.; Pannecoucke, X.; Charette, A. B.; Jubault, P.

45. Introduction of Functionalized Difluoromethylated Building Blocks Mediated or Catalyzed by Copper. (Account Article – invitation)

Synlett 201627, 2314.

Pannecoucke, X.; Poisson, T.

44. New Entries Toward the Synthesis of OCF3-Containing Molecules. (Highlight)

Org. Chem. Front. 20163, 1004.

Besset, T.; Jubault, P.; Pannecoucke, X.; Poisson, T.

43. New Prospects Toward the Synthesis of Difluoromethylated Phosphates Mimics. (Concept article – invitation)

Chem. Eur. J. 201622, 10284.

Ivanova, M. V.; Bayle, A.; Besset, T.; Pannecoucke, X.; Poisson, T.

42. Catalytic Enantioselective Synthesis of Halo-Cyclopropanes.

Chem. Eur. J. 2016, 22, 6239.

Pons, A.; Ivashkin, P.; Poisson, T.; Charette, A. B.; Pannecoucke, X.; Jubault, P.

41. Palladium-Catalyzed Synthesis of a-Trifluoromethylstyrenes by Means of Directed C-H Bond Functionalization.

Eur. J. Org. Chem. 2016, 76.

Zhao, Q.; Besset, T.; Poisson, T.; Bouillon, J.–P.; Pannecoucke, X.

 

2015 (10)

40. Copper-Mediated Formation of Aryl, Heteroaryl, Vinyl and Alkynyl Difluoromethylphosphonates: A General Approach to Fluorinated Phosphate Mimics.

Angew. Chem. Int. Ed. 201554, 13406.

Ivanova, M. V.; Bayle, A.; Besset, T.; Poisson, T.; Pannecoucke, X.

39. 1,4-Addition of the CF3 Group, Perfluoroalkyl Groups and Functionalized Difluoromethylated Moieties: an Overview. (Review)

J. Fluorine Chem. 2015178, 225.

Besset, T.; Poisson, T.; Pannecoucke, X.

38. Synthesis and Reactivity of N-tert-Butanesulfinyl Glycosylamines.

Eur. J. Org. Chem. 2015, 4330.

Cocaud, C; Nicolas, C.; Bayle, A.; Poisson, T.; Pannecoucke, X.; Martin O. R.

37. Recent Progress Toward the Introduction of Functionalized Difluoromethylated building blocks. (Review)

Chem. Eur. J. 201521, 12836.

Belhomme, M.-C.; Besset, T.; Poisson, T.; Pannecoucke, X.

36. Copper-Mediated Synthesis of Aryl Difluoromethylphosphonates: A Sandmeyer Approach.

Eur. J. Org. Chem. 2015, 3787.

Bayle, A.; Cocaud, C; Nicolas, C.; Martin O. R.; Poisson, T.; Pannecoucke, X.

35. Direct Vicinal Difunctionalization of Alkynes: An Efficient Approach Toward the Synthesis of Highly Functionalized Fluorinated Alkenes. (Review)

Eur. J. Org. Chem. 2015, 2765.

Besset, T.; Poisson, T.; Pannecoucke, X.

34. Rhodium-Catalyzed Cyclopropanation of Fluorinated Olefins: a Straightforward Route to Highly Functionalized Fluorocyclopropanes.

Org. Lett. 201517, 1790.

Pons, A.; Beucher, H.; Ivashkin, P.; Lemonnier, G.; Poisson, T.; Charette, A. B.; Jubault, P.; Pannecoucke, X.

33. Synthesis and Immunological Evaluation of Fluorinated a-C-Galactosylceramides.

J. Fluorine Chem. 2015173, 84.

Colombel, S.; Van Hifjte, N.; Poisson, T.; Pannecoucke, X.; Monneaux, F.; Leclerc, E.

32. Copper-Catalyzed Innate Ethoxycarbonyldifluoromethylation of Electron-Rich Arenes.

Eur. J. Org. Chem.  2015, 1719.

Belhomme, M.-C.; Bayle, A.; Poisson, T.; Pannecoucke, X.

31. First Synthesis of N-Acetyl-glycosamine-1-Difluoromethylphosphonate From 2-Nitroglycals as Phosphate Analog.

J. Fluorine Chem. 2015171, 56.

Delaunay, T.; Poisson, T.; Jubault, P.; Pannecoucke, X.

 

2014 (11)

30. Recent Progress in Direct Introduction of Fluorinated Groups on Alkenes and Alkynes by means of C-H Bond Functionalization. (Review)

Chem. Eur. J. 201420, 16830.

Besset, T.; Poisson, T.; Pannecoucke, X.

29. 2-Nitro-Glycals Versatile Building Blocks Toward the Synthesis of 2-AminoGlycosides. (Review)

Eur. J. Org. Chem. 2014, 7525.

Delaunay, T.; Poisson, T.; Jubault, P.; Pannecoucke, X.

28. Straightforward Access to Difluoromethylated Alkynes via a Castro-Stephens Reaction.

Eur. J. Org. Chem. 2014, 7220.

Besset, T.; Poisson, T.; Pannecoucke, X.

27. Copper Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C2-CF2H Furans and Benzofurans.

J. Org. Chem. 201479, 7205.

Belhomme, M.-C.; Poisson, T.; Pannecoucke, X.

26. Copper Catalyzed Selective Difluoroacetylation of Enamides by Means of C-H Bond Functionalization.

Chem. Commun. 201450, 5887.

Caillot, G.; Dufour, J.; Belhomme, M.-C.; Poisson, T.; Grimaud, L.; Pannecoucke, X.; Gillaizeau, I.

25. Direct Copper Mediated Functionalization of Unsaturated C-C Bonds using BrCF2CO2Et: a Straightforward Access to Highly Valuable Difluoroacetylated Alkenes.

(invitation, Special Topic Issue on “Copper Chemistry” ed. Prof. E. M. Carreira)

Synthesis 201446, 1859.

Belhomme, M.-C.; Dru, D.; Xiong, H.-Y.; Cahard, D.; Besset, T.; Poisson, T.; Pannecoucke, X.

24. Stereoselectivity of the Honda-Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with a-Oxygenated Sulfinylimines.

J. Org. Chem. 201479, 4186.

Fontenelle, C. Q.; Conroy, M.; Light, M.; Poisson, T.; Pannecoucke, X.; Linclau, B.

23. Efficient Access to Fluorinated Homoallylic Alcohols through an Indium Promoted Fluoroallylation Reaction.

Tetrahedron 201470, 3123.

Lemonnier, G.; Van Hijfte, N.; Sebban, M.; Poisson, T.; Couve-Bonnaire, S.; Pannecoucke, X.

22. Stereoselective Access to b-C-glycosamines by Means of a Nitro-Michael Addition of Organolithium Reagents.

Eur. J. Org. Chem. 2014, 3341.

Delaunay, T.; Poisson, T.; Jubault, P.; Pannecoucke, X.

21. Indium Promoted Diastereoselective Addition of Fluorinated Halo-Allylic Derivatives to Imines.

J. Org. Chem. 201479, 2916.

Lemonnier, G.; Van Hijfte, N.; Poisson, T.; Couve-Bonnaire, S.; Pannecoucke, X.

20. Study of the PAH and water-extractable phenols content in used cross ties collected on the French rail network.

Chemosphere 2014111, 1.

Marcotte, S.; Poisson, T.; Koltalo, F.; Aubray, M.; Basle, J.; De Bort, M.; Giraud, M.; Nguyen Hoang, T.; Octeau, C.; Blondeel C.

 

2013 (5)

19. Addition of Electrophilic Radicals to 2-Benzyloxyglycals: Synthesis and Functionalization of Fluorinated a-C-Glycosides and Derivatives.

Chem. Eur. J. 201319, 12778.

Colombel, S.; Van Hifjte, N.; Poisson, T.; Leclerc, E.; Pannecoucke, X.

18. Copper Catalyzed b-Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C-H Functionalization.

Org. Lett. 201315, 3428.

Belhomme, M.-C.; Poisson, T.; Pannecoucke, X.

17. A Practical and Straightforward Access to Fluorinated Homoallylic Alcohols in Aqueous Media.

Tetrahedron Lett. 201354, 2821.

Lemonnier, G.; Poisson, T.; Couve-Bonnaire, S.; Pannecoucke, X.

16. Diethylzinc-Mediated Addition of 2,2-Dibromo-2-fluoroacetamides to Carbonyl Compounds: Synthesis of a-Bromo-a-fluoro-b-hydroxy Amides and/or Z-Fluorovinyl Amides.

Eur. J. Org. Chem. 2013, 3278.

Lemonnier, G.; Poisson, T.; Couve-Bonnaire, S.; Jubault, P.; Pannecoucke, X.

15. Copper Catalyzed Direct Arylation of Cyclic Enamides using Diaryliodonium Salts.

Org. Lett. 201315, 278.

Gigant, N.; Chausset-Boissarie, L.; Belhomme, M.-C.; Poisson, T.; Pannecoucke, X.; Gillaizeau, I.

 

2012 (1)

14. Indium Promoted Reformatsky Reaction: A Straightforward Access to b-amino and b-hydroxy a,a-difluoro Carbonyl Compounds.

J. Org. Chem. 201277, 9277.

Poisson, T.; Belhomme, M. -C.; Pannecoucke, X.

 

Prior INSA Rouen Normandie (13)

13. Tetrahedron Lett. 201253, 3284. 

12. Chem. Commun. 201147, 10629.

11. Chem. Commun. 201147, 9615.

10. J. Org. Chem. 201075, 7704.

9. J. Am. Chem. Soc. 2010, 132, 7890.

8. J. Org. Chem. 201075, 963.

7. Synlett 2009, 2437.

6. J. Org. Chem. 200974, 3516.

5. Synlett 2008, 2447.

4. Synlett 2008, 147.

3. Angew. Chem. Int. Ed. 2007, 46, 7090.

2. Synlett 2007, 381.

1. Synlett 2005, 2285.

Fundings

    

Institutional Funding

Regional Funding

National Funding

Private Funding

INSA Rouen Normandie

CNRS

Rouen University

Région Normandie

Labex SynOrg

I2C (Institut Chimie Carnot)

Institut Universitaire de France

ANR (agence national pour a recherche)

  IDECHEM – ORIL Industrie

  Janssen Pharmaceuticals

International Funding

CEFIPRA 

Alumni

Graduate Students

Marie Charlotte Belhomme (2011-2014)                

Maria Ivanova (2014-2017)                                   

Amandine Pons (2014-2017)                                  

Qun Zhao (2014-2017)                                           

Elodie Carbonnel (2015-2018)                              

Wei-Sheng Huang (2016-2019)

Postdoctoral Research Associate

Dr. Gérald Lemonnier (2012 – 2013)

 Dr. Nathalie Van Hijfte (2013 – 2014)

Dr. Thierry Delaunay (2013 – 2014)

Dr. Thierry Delaunay (2014 – 2015)

Dr. Alexandre Bayle (2014-2015)

Dr. Gilles Caillot (2015 – 2016) 

Dr. Adeline René (2015 – 2016)

Dr. Maxence Bos (2016)

Dr. Alexandre Bayle (2016 – 2017)

Dr. Fabien Gelat (2016 – 2017)

Dr. Vincent Barbier (2016 – 2017)

Dr. Alicia Dilmaç (2017 – 2018)

Dr. Jianjun Wang (2017-2018)

Dr. Antoine Nitelet (2018)

Dr. Marie-Léonie Delcourt (2019-2020)

Contact: thomas.poisson@insa-rouen.fr