COBRA - Chimie organique et bioorganique - réactivité et analyse


COBRA lab is supported by CNRS (French national research center for science, label UMR6014), Normandy University of Rouen and INSA Rouen Normandy. It is integrated into the Normandy doctoral school of chemistry and the Norman- dy network for research “Biomedical and Chemistry”. It plays a central part in the «Institut Carnot» I2C, and is member of the Laboratory of Excellence SynOrg.

Research fields

  • Analysis and modeling
  • Bio-organic chemistry
  • Synthesis of fluorinated biomolecules
  • Exploratory methodologies for organic and organometallic synthesis
  • Heterocycles

Application areas

  • Pharmaceutical industry
  • Cosmetics
  • Energy
  • Agri-food
  • Environment

Know-how and expertise

Analysis and modeling
Molecular and supramolecular mass spectrometry, NMR and molecular modeling, theoretical chemistry.

Organicandorgano-metallic synthesis
Organo (bi) metals in enantioselec- tive synthesis, carbometalation of alkenes and alkynes, organome- tallic, organocatalytic and natural product synthesis methodologies, continuous organic synthesis and reactivity, organic synthesis under ultra high pressure.

Bioorganic chemistry
Chemistry of organic fluorophores, probe for imaging, medicinal chemistry and reactivators, immunoenzymatic detection of toxins, synthetic methodology.

Fluorinated biomolecules synthesis
New methods of synthesis in organofluorinated chemistry, elaboration and synthesis of fluorinated biomolecules.

Pharmacochemistry of heterocycles, direct functionalization of the C-H bond of heterocycles, organocatalysis.



Advanced equipment

  • 6 NMR: 600 MHz, 500 MHz, 400 MHz and 3 x 300 MHz
  • Mass Spectrometry: FT-ICR ultra-high resolution, Q-IM-TOF- MS, MALDI-TOF-MS, LC-MSMS, GCMS ...
  • ICP-MS
  • equipment for continuous flow and microfluidic synthesis
  • high pressure devices ...

A wide range of collaborations

tific success of the laboratory and more than 50 patents have been filed since its creation. COBRA is also the winner of an ERC. The skills of COBRA are widely exported: Germany, England, Italy, Spain, Switzerland, United States, Japan ...


Laboratoire COBRA
Bâtiment IRCOF - 1, rue Tesnière
76821 Mont-Saint-Aignan cedex
tél : 02 35 52 24 00

Direction : Xavier PANNECOUCKE

More information

Download the COBRA file